The rapid increase of mobile users, subscriber demands, and various enabling technologies of next-generation mobile and wireless communication systems such as 4G, 5G, WiMAX, and many more have triggered antenna researchers to develop new solutions. The evolving technologies such as mmWave, 5G require high gain and high capacity antennas. The rising demands for small size, low-cost, low-profile, and efficient multi-band antennas in a single system for various communication standards have also created many opportunities for researchers. The design and development of such multi-band and compact size antenna requires more attention towards other limitations like gain, directivity, bandwidth, high efficiency, various frequency bands, operating set-up, design complexity, etc. Microstrip antenna has characteristics like simple structure, small size, cost-effective and easy integration with Microwave Integrated Circuits. This review paper aims to overview the current research trends and presents the various approaches, design, and development techniques used by researchers in multi-band antennas comprising 5G wireless systems. This study will help the researchers to review and analyze the existing methodologies, design procedures, and future challenges.