Athletes encounter different types of hits, which sometimes could be strong or light hits. Heavy or strong hits on some parts of an athlete’s body such as the chest or lungs may be harmful and cause severe damage to the human body. In some cases, the heavy hits may cause heart failure or a serious lung rupture. In the athlete’s healthcare domain, there are potential trails efforts based on Internet-of-Thing (IoT) technology; however, building a comprehensive and efficient system is still a demanding concern. In this paper, we present a new comprehensive real-time platform for monitoring athletes during Mixed Martial Arts (MMA). The proposed real-time monitoring platform is called the IoT-Sports Health system, which particularly fuses based on IoT devices with in-sport healthcare services. Therefore, our proposed system is integrated, designed, and implemented to monitor and measure the athlete’s body temperature, strike force, and the number of strikes that the athlete has been received from the opponent. Several real field trials and many experiments proved the feasibility of our proposed IoT-Sport health system, which directly and automatically plays a significant role in chest guarding against heavy and strong strikes. Furthermore, our proposed real-time monitoring system can be easily deployed to monitor aging people that suffering from chronic diseases in-home. In conclusion, experimental tests are performed to evaluate the proposed IoT-Sports Health system by applying a real case on three different matches. The obtained results proved that our proposed IoT-Sports Health system outperforms similar systems with respect to the accuracy, and regarding to the response time.