This article illustrates a design approach for capturing, storing, indexing, and search of African traditional herbal medicine (ATHMed) framed on a hybrid-based knowledge model for efficient preservation and retrieval. By the hybrid approach, the framework was developed to include both the use of machine learning and ontology-based techniques. The search pattern considers ontology design and machine learning techniques for extracting ATHMed data. The framework operates on a semantically annotated corpus and delivers a contextual and multi-word search pattern against its knowledge base. In line with design science research, preliminary data were collected in this study, and a proposed strategy was developed toward processing, storing and retrieving data. While reviewing literature and interview data to reflect on the existing challenges, these findings suggest the need for a system with the capability of retrieving and archiving ATHMed in Ghana. This study contributes to SDG 3 by providing a model and conceptualizing the implementation of ATHMed. We, therefore, envision that the framework will be adopted by relevant stakeholders for the implementation of efficient systems for archival and retrieval of ATHMed.