In the implementation of Digital Forensics, one of the derivatives of practice is the handling of Digital Evidence. Handling Digital Evidence requires important steps and procedures. Digital evidence is a source of artifacts in handling a digital-based crime case, one of which comes from digital storage. In this research, the author will design a framework for Digital Forensic investigations by simulating digital evidence in the form of a non-volatile architecture. The reference commonly used by researchers in previous articles is the National Institute of Justice (NIST). The framework is a reference and steps in the practice of acquiring digital evidence. The purpose of designing this framework is as a legal procedure that is specifically implemented in the practice of acquiring non-volatile digital evidence. In the design, the author conducted a literature study on the NIST SP 800-86 and ISO 27037:2012 standards and then combined them in a hybrid terminology. The output of this research is to combine the two standards to become framework as reference for handling and investigating Digital Forensic science.